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English Brand Name & Chinese Name
Padcev^®; 備思復凍晶注射劑

Drug Introduction
Enfortumab vedotin is an antibody–drug conjugate (ADC) that combines a monoclonal antibody with a small-molecule cytotoxic drug, specifically targeting and killing tumor cells. Clinically, it can be used alone or in combination with other drugs to treat locally advanced or metastatic urothelial carcinoma.

How It Is Administered
Administered as an intravenous infusion over at least 30 minutes. The treatment interval and number of doses are determined by the physician based on clinical judgment.

Precautions Before and During Administration

• Before starting treatment, inform your doctor if you have any of the following conditions:
  • Eye disease
  • Respiratory or lung disease
  • Liver disease
  • Diabetes
• Enfortumab vedotin may lower white blood cell counts, increasing infection risk. During treatment, avoid crowded places, maintain good personal hygiene, and seek medical attention promptly if you develop fever, chills, sore throat, or flu-like symptoms.
• It may also cause low platelet counts and anemia. Notify your doctor immediately if you experience unexplained bruising or bleeding, weight loss, or unusual fatigue.
• If you require vaccinations during treatment, consult your doctor first.
• Avoid pregnancy during treatment; if pregnancy is suspected, inform your doctor immediately.
• Do not breastfeed during treatment and for at least 6 months after the last dose.
• Enfortumab vedotin may harm an unborn baby. Women should use effective contraception during treatment and for at least 6 months after the last dose; men should use effective contraception for at least 4 months after the last dose.
• It may cause high blood sugar. If you have diabetes, inform your doctor before starting treatment and monitor your blood sugar closely during therapy.

Possible Side Effects

• Allergic reactions: If itching, rash, swelling of the face or hands, swelling or tingling of the lips or throat, chest tightness, difficulty breathing, dizziness, or palpitations occur during infusion, notify healthcare personnel immediately.
• Skin reactions: Rash and itching are common. Severe skin reactions may occur in rare cases. Seek immediate medical attention if you notice spreading or worsening skin lesions (blistering, peeling), fever, swollen lymph nodes, flu-like symptoms, sores in the mouth or genital area, or redness of the conjunctiva.
• Gastrointestinal symptoms: Commonly diarrhea, constipation, nausea, vomiting, abdominal pain, loss of appetite, and changes in taste.
• Peripheral neuropathy: If you experience tingling, numbness in your fingertips or toes, or muscle weakness, notify your doctor promptly.
• Dry eyes: Artificial tears can help relieve discomfort. Notify your doctor if you experience worsening dryness, excessive tearing, blurred vision, or changes in vision.
• High blood sugar: If you feel unusually thirsty, urinate more often, feel hungrier than usual, suddenly have blurred vision, headaches, or fruity-smelling breath, seek medical attention promptly.
• Pneumonia / interstitial lung disease: Enfortumab vedotin can cause varying degrees of lung inflammation, which may present as shortness of breath, difficulty breathing, cough, wheezing, or fatigue; in severe cases, it can be life-threatening. Seek medical help immediately if you develop unexplained fever or new/worsening lung or respiratory symptoms.

Dietary Considerations

• Inform your doctor if you are taking any over-the-counter medications, herbal supplements, or vitamins.
• Avoid raw or undercooked foods, as well as expired or spoiled food, to reduce infection risk during treatment due to lowered immunity.
• If you have special dietary needs or questions, you may schedule a nutrition consultation for personalized advice from a dietitian.