Classification of Plasmodium vivax as artefactual cells by the CellaVision DM9600: a system limitation in a non-endemic area

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Classification of Plasmodium vivax as artefactual cells by the CellaVision DM9600: a system limitation in a non-endemic area

Abstract
A 46-year-old Taiwanese man returning from Indonesia presented with fever and thrombocytopenia. An automated cellular morphology analyzer flagged artefactual cells without a definitive diagnosis. Peripheral blood smear and PCR confirmed Plasmodium vivax. He was treated with artemether–lumefantrine and primaquine, with rapid recovery and no relapse.

這篇學術文章探討了非瘧疾流行地區（如台灣）在診斷輸入性間日瘧（Plasmodium vivax）時面臨的挑戰。內容記錄了一名從印尼返台的男子起初被誤診為登革熱，隨後透過數位形態分析儀（CellaVision DM9600）意外發現異常細胞，最終經由手工顯微鏡檢測與PCR技術確診為瘧疾。研究指出，雖然自動化系統能提升效率，但其演算法常將瘧原蟲錯誤分類為人造細胞（artefactual cells），顯示出技術上的限制。作者強調，在瘧疾已根除的地區，醫檢師的人工判讀經驗與詳細的旅遊史查詢對於防止漏診至關重要。文章最後呼籲應將人工智慧（AI）整合至數位診斷工具中，以強化對罕見傳染病的偵測能力。

全文連結: https://pubmed.ncbi.nlm.nih.gov/42097914/

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